ABSTRACT
Cancer is a cellular tumor that unlike benign tumor can metastasize and invade the surrounding tissues. In the present study the anticancer effect of paclitaxel was evaluated on 7, 12 Di Methyl Benz (a) Anthracene induced skin cancer in wistar rats and results were compared with normal, paclitaxel and paclitaxel-Di allyl sulfide combined alternative chemotherapy. By analyzing the various biochemical parameters (lipid Profile and lipid metabolizing enzymes) and Marker enzymes (squamous cell antigen). Skin cancer was induced in rats by 7, 12 Di methyl benz(a) anthracene (DMBA) at the dosage of 5 μg was dissolved in 100μl and administered into experimental animals for 28 weeks. In this study, we demonstrated that combination of paclitaxel and Di allyl sulfide protects the rats from a lethal dose of DMBA for 30 days. Total cholesterol (TC), free cholesterol (FC), phospholipids (PL) and triglycerides (TG) were found to be significantly increased whereas ester cholesterol (EC) and free fatty acids (FFA) were significantly decreased when compared with cancer bearing group II animals. From the present study, the effect of Paclitaxel- Di allyl sulfide combination proved to be a more significant chemotherapeutic agent against DMBA induced skin cancer in wistar rats compared to that of paclitaxel by analyzing the lipid profile and lipid metabolizing enzymes and marker enzymes.
ABSTRACT
Background: Even though alcoholic liver disease is common disease in India, there are only limited reports about insulin resistance and no reports about lipid bound sialic acid in these cases. The present study was designed to evaluate insulin resistance and lipid bound sialic acid levels in patients with alcoholic liver disease Materials and methods: 50 alcohol liver disease cases groups [Fatty liver (n=18), alcoholic hepatitis (n=19) and cirrhosis (n=13)] and 38 controls were enrolled in the study. Fasting insulin, lipid bound sialic acid and liver function test parameters were analyzed in both the groups Results: Insulin, homeostasis model of insulin resistance and lipid bound sialic acid were significantly increased in alcohol liver disease cases compared to controls. Both insulin and insulin resistance were higher in alcoholic hepatitis and cirrhosis group compared to fatty liver group and controls Conclusion: To conclude, the present study demonstrates increased insulin resistance and lipid bound sialic acid in patients with ALD.